There is a firm commitment to inner-city building in unprecedentedly high densities. To this end, new building typologies are being introduced, such as the hybrid city block with high-rise buildings and large-scale complexes with micro housing. This densification is accompanied by many challenges: preserving the human scale; space for work; space for greenery; strengthening well-being; large-scale micro-housing; accessibility and liveability. Our practice-oriented research quickly takes stock of new developments; and systematically experiments with new solution approaches, such as neuroarchitecture.